Ortho-aminoazotoluene activates mouse constitutive androstane receptor (mCAR) and increases expression of mCAR target genes
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چکیده
منابع مشابه
Residue threonine 350 confers steroid hormone responsiveness to the mouse nuclear orphan receptor CAR.
Steroid hormones modulate activity of the nuclear receptor constitutive active receptor (CAR, or constitutive androstane receptor) in mouse liver. Progesterone and testosterone repress the constitutive activity of mouse CAR (mCAR) in cell-mediated transfection assays, whereas estrogens activate the repressed receptor. This repression and activation is not observed with human CAR. To define the ...
متن کاملThe environmental estrogen, nonylphenol, activates the constitutive androstane receptor.
Nonylphenol (NP) and its parent compounds, the nonylphenol ethoxylates are some of the most prevalent chemicals found in U.S. waterways. NP is also resistant to biodegradation and is a known environmental estrogen, which makes NP a chemical of concern. Our data show that NP also activates the constitutive androstane receptor (CAR), an orphan nuclear receptor important in the induction of detoxi...
متن کاملThe Nrf2 activator oltipraz also activates the constitutive androstane receptor.
Oltipraz (OPZ) is a well known inducer of NAD(P)H:quinone oxidoreductase (NQO1) along with other enzymes that comprise the nuclear factor E2-related factor 2 (Nrf2) battery of detoxification genes. However, OPZ treatment also induces expression of CYP2B, a gene regulated by the constitutive androstane receptor (CAR). Therefore, this study was designed to determine whether OPZ induces gene expre...
متن کاملValproic Acid induces CYP3A4 and MDR1 genes expression by activation of Constitutive Androstane Receptor and Pregnane X Receptor pathways
Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Hradec Kralove (L.C., L.S., F.S., P.P.), Institute of Medical Chemistry and Biochemistry (E.A., R.V., Z.D., J.U.), and Department of Pharmacology (P.A.), Faculty of Medicine, Palacky University, Olomouc, Czech Republic DMD Fast Forward. Published on March 28, 2007 as doi:10.1124/dmd.1...
متن کاملRegulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site.
The CYP2C subfamily metabolizes many clinically important drugs. These genes respond to prototypical inducers such as phenobarbital and rifampicin, yet little has been reported on the mechanisms of induction. This report examines the regulation of CYP2C9 with respect to two specific receptors thought to be involved in phenobarbital (PB) induction, the constitutive androstane receptor (CAR) and ...
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ژورنال
عنوان ژورنال: Toxicology and Applied Pharmacology
سال: 2011
ISSN: 0041-008X
DOI: 10.1016/j.taap.2011.05.019